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cimetidine will boost the degree or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.Contraindicated (1)nirmatrelvir will improve the stage or effect of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.fedratinib will improve the amount or effect of sildenafil by influencing hep